The health beneficial effects of an Asparagus racemosus root, although many in-vitro studies revealed a striking variety of biochemical and pharmacological properties data about the beneficial effects of A. racemosus root in whole organisms, especially with respect to ageing, are quite limited. We used the well established model organism C. elegans to elucidate the protective effects of A. racemosus root extract. Significant characteristic for the gerontology research is recognition and study of compound that delay aging and extend lifespan. These studies can set up the base for the treatments that might delay normal human aging and gave protection against different stress condition. This research article focuses on the dose dependent treatments of C. elegans with the A. racemosus root extract. Extracts have been shown to increase the resistance of organisms against the damaging effect of different stress conditions. We observe that A. racemosus extracts also boost the mean lifespan of the nematode C. elegans in a dose-dependent way. Through three independent experiments we found that, 1 mg/ml A. racemosus significantly increased life span 30.93% (P<0.0001), increased the maximum lifespan with 4-4.5 days in lifespan assay and in different stress condition increased life span 13-20% (P<0.0001). With higher concentrations, toxic effect was observed, whereas at the highest concentrations tested (2500 µg/ml A. racemosus) a lifespan shortening effect was observed of 5%. Based on the observation of present study, it was suggested that A. racemosus are proficient as anti-stress agent their optimize concentration increased stress resistance and increase the lifespan of nematode.
Loading....